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4-Hydroxybenzoic Acid → 4-(tetrahydro-2H-pyran-2-yloxy)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Hydroxybenzoic Acid | HCID 135 | — |
| 反応物 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 反応物 | Pyridinium.p-toluenesulfonate | HCID 22033616 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-(tetrahydro-2H-pyran-2-yloxy)benzoic acid | HCID 11183645 | — |
反応手順
To an ice-cooled mixture of 4-hydroxybenzoic acid (13.81 g) in 250 ml of diethylether containing 1.98 g of pyridinium p-toluenesulphonic acid, 3,4-dihydro-2H-pyran (16 g) was drop wise added. After complete addition stirring was continued at temperature below +8° C. for 4 h and the white precipitate was filtered off, washed twice with 100 ml of +4° C. pre-cooled diethylether and dried to give nearly pure 4-(tetrahydro-2H-pyran-2-yloxy)benzoic acid as white powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08105662B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-c7763484ead34970ac2552da47af3675 |
| 出典メモ | uspto-grants-2012_01 |