1,2-Dichloroethane → (2S)-2-methylbutyl 2,5-bis[(4-{[6-(acryloyloxy)hexyl]oxy}benzoyl)oxy]benzoate

HRID 424308ノート

反応式

HRID 424308 の反応式
[C:1]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=1)(=[O:4])[CH:2]=[CH2:3].O[C:23]1[CH:36]=[CH:35][C:34]([OH:37])=[CH:33][C:24]=1[C:25]([O:27][CH2:28][C@@H:29]([CH3:32])[CH2:30][CH3:31])=[O:26].[CH2:38](Cl)[CH2:39]Cl>CN(C1C=CN=CC=1)C.C(Cl)Cl>[C:1]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([C:17]([O:19][C:23]2[CH:36]=[CH:35][C:34]([O:37][C:17](=[O:18])[C:16]3[CH:15]=[CH:14][C:13]([O:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][O:5][C:1](=[O:4])[CH:38]=[CH2:39])=[CH:21][CH:20]=3)=[CH:33][C:24]=2[C:25]([O:27][CH2:28][C@@H:29]([CH3:32])[CH2:30][CH3:31])=[O:26])=[O:18])=[CH:20][CH:21]=1)(=[O:4])[CH:2]=[CH2:3]

参加物

6

反応物 3

HCID 111,2-DichloroethaneHCID 37135654-((6-(Acryloyloxy)hexyl)oxy)benzoic acidHCID 59005024(2S)-2-methylbutyl 2,5-dihydroxybenzoate

生成物 1

HCID 59005014(2S)-2-methylbutyl 2,5-bis[(4-{[6-(acryloyloxy)hexyl]oxy}benzoyl)oxy]benzoate

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture consisting of 4-{[6-(acryloyloxy)hexyl]oxy}benzoic acid (2.92 g), (2S)-2-methylbutyl 2,5-dihydroxybenzoate (1.1 g), DMAP (0.24 g) and EDC (2 g) in CH2Cl2 (30 ml) was stirred for 6 h at room temperature. The yellowish reaction mixture was then evaporated to dryness and the obtained pasty residue was purified by column chromatography over silica to give nearly pure material as transparent oil which becomes pasty upon standing for about 24 h.

後処理

  1. customThe yellowish reaction mixture
  2. customwas then evaporated to dryness
  3. customthe obtained pasty residue was purified by column chromatography over silica
  4. customto give nearly pure material as transparent oil which
  5. waitupon standing for about 24 h.

出典と根拠

ORDレコード
ord-14bc3a45110c4d50afb991f214510206
出典データセット
uspto-grants-2012_01
特許番号
US08105662B2

反応ノート

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