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5-Methyl-3-hexen-2-one → 3-(aminomethyl)-4-isopropyl-6-methylpyridin-2(1H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Methyl-3-hexen-2-one | HCID 5363140 | — |
| 反応物 | 3-(Aminomethyl)-6-methyl-4-propylpyridin-2(1H)-oneacetate | HCID 67124140 | — |
| 生成物 | 3-(aminomethyl)-4-isopropyl-6-methylpyridin-2(1H)-one | HCID 67124337 | — |
反応手順
The title compound was prepared in the same manner as described for 3-(aminomethyl)-6-methyl-4-propyl-2(1H)-pyridinone (Intermediate 5) using (3E)-5-methyl-3-hexen-2-one (20 g, 137 mmol). LCMS E-S (M+H)=181.1. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.8-11.9 (br s, 1H), 7.86-7.96 (br s, 3H), 6.10 (s, 1H), 3.82-3.86 (m, 2H), 3.02-3.09 (m, 1H), 2.17 (s, 3H), 1.08 (d, 6H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536179B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-8ccecef1c9904cf08acb2dc867195ba4 |
| 出典メモ | uspto-grants-2013_09 |