Benzoyl Peroxide → 3-(Bromomethyl)isothiazolo[5,4-b]pyridine
反応式
[Br:1]NC(=O)CCC(N)=O.[CH3:10][C:11]1[C:19]2[C:14](=[N:15][CH:16]=[CH:17][CH:18]=2)[S:13][N:12]=1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:1][CH2:10][C:11]1[C:19]2[C:14](=[N:15][CH:16]=[CH:17][CH:18]=2)[S:13][N:12]=1参加物
5
実験手順
N-Bromosuccinamide (10.7 mmol) was added to a solution of 3-methylisothiazolo[5,4-b]pyridine (10.0 mmol) in carbontetrachloride (20 mL). Benzoyl peroxide (0.82 mmol) was added and the reaction mixture was heated at reflux for 48 h. The reaction mixture was filtered through Celite (ethyl acetate) and the eluent was concentrated to provide crude 3-(bromomethyl)isothiazolo[5,4-b]pyridine as a yellow solid.
後処理
- temperaturethe reaction mixture was heated
- temperatureat reflux for 48 h
- filtrationThe reaction mixture was filtered through Celite (ethyl acetate)
- concentrationthe eluent was concentrated
出典と根拠
- ORDレコード
- ord-b478c96bbd39448c9af2860e121b0708
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08106066B2
反応ノート
読み込み中…