Hydrochloric Acid → (4,6-Dimethylpyrimidin-2-yl)cyanamide

HRID 4247

反応式

HRID 4247 の反応式
[C:1]([NH:3][C:4]([NH2:6])=[NH:5])#[N:2].[CH3:7][C:8](=O)[CH2:9][C:10](=O)[CH3:11].Cl>O>[C:1]([NH:3][C:4]1[N:6]=[C:10]([CH3:11])[CH:9]=[C:8]([CH3:7])[N:5]=1)#[N:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 31261AcetylacetoneHCID 178418324HCID 178418324、化合物

生成物 1

HCID 521618(4,6-Dimethylpyrimidin-2-yl)cyanamide収率 70%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
120 °C

実験手順

A mixture of 42 g (0.5 mol) of cyanoguanidine ("dicyanodiamide") and 50 g (0.5 mol) of 2,4-pentanedione ("acetylacetone") is heated to 120° C. for 15 hours. The reaction mixture is then cooled, after which 500 ml of water are added and the solution is acidified with hydrochloric acid at 0° C. to 10° C. The product obtained in crystalline form during this procedure is isolated by filtering it off under suction. 51.8 g (70% of theory) of 2-cyanoamino-4,6-dimethyl-pyrimidine of melting point 205° C. are obtained.

後処理

  1. temperatureThe reaction mixture is then cooled
  2. customThe product obtained in crystalline form during this procedure
  3. customis isolated
  4. filtrationby filtering it off under suction

出典と根拠

ORDレコード
ord-337e60123b3b4db0a8dbe09ecff88ae9
出典データセット
uspto-grants-1988_02
特許番号
US04725303

関連ノート

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