Triacetoxyperiodinane → 2-Butoxy-4-formyl-benzoic Acid Methyl Ester

HRID 424804ノート

反応式

HRID 424804 の反応式
[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][OH:11])=[CH:6][C:5]=1[O:12][CH2:13][CH2:14][CH2:15][CH3:16].C(=O)(O)[O-].[Na+].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]=[O:11])=[CH:6][C:5]=1[O:12][CH2:13][CH2:14][CH2:15][CH3:16]

参加物

5

反応物 3

HCID 159087TriacetoxyperiodinaneHCID 516892Sodium BicarbonateHCID 574433312-Butoxy-4-hydroxymethyl-benzoic acid methyl ester

生成物 1

HCID 574433192-Butoxy-4-formyl-benzoic Acid Methyl Ester収率 90%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a 0° C. solution of 2-butoxy-4-hydroxymethyl-benzoic acid methyl ester (0.270 g, 1.13 mmol) in methylene chloride (10 mL) are added sodium bicarbonate (0.14 g, 1.7 mmol) and Dess-Martin periodinane (0.58 g, 1.4 mmol) sequentially. The reaction mixture is stirred at room temperature for 1.0 h and quenched with water (10 mL). The reaction mixture is partitioned between CH2Cl2 (30 mL) and water (20 mL). The organic phase is washed with brine (20 mL), dried (Na2SO4), filtered, and concentrated under reduced pressure to a residue. The residue is purified by flash chromatography to give the title compound as a syrup (240 mg, 90%). LC-ES/MS: 237.3 (M+1).

後処理

  1. customquenched with water (10 mL)
  2. customThe reaction mixture is partitioned between CH2Cl2 (30 mL) and water (20 mL)
  3. washThe organic phase is washed with brine (20 mL)
  4. dry with materialdried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure to a residue
  7. customThe residue is purified by flash chromatography

出典と根拠

ORDレコード
ord-99949e92b5c44cb09b689d2a1661b8de
出典データセット
uspto-grants-2012_01
特許番号
US08106077B2

反応ノート

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