C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Cl:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:22]=1[N:28]1[C:32]([CH2:33]O)=[C:31]([C:35]([F:38])([F:37])[F:36])[N:30]=[N:29]1.C(Br)(Br)(Br)[Br:40]>ClCCl>[Br:40][CH2:33][C:32]1[N:28]([C:22]2[C:21]([Cl:20])=[CH:26][CH:25]=[CH:24][C:23]=2[Cl:27])[N:29]=[N:30][C:31]=1[C:35]([F:38])([F:37])[F:36]Triphenylphosphine (16.4 g, 62.5 mmol) is added to a suspension of [3-(2,6-dichlorophenyl)-5-trifluoromethyl-3H-[1,2,3]triazol-4-yl]-methanol (13 g, 41.69 mmol) in dichlormethane (80 mL). The mixture is cooled to 0° C. and carbon tetrabromide (20.7 g, 62.5 mmol) is added. The reaction is stirred at room temperature for 1.5 hours. The solvent is evaporated under reduced pressure and the residue is purified by flash chromatography eluting with hexanes/EtOAc (95:5 to 8:2) to obtain the title compound (15.6 g, 96% yield). ES/MS m/e 374 (M+1).
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