化工社化工社 化学情報印刷レポート · 研究参考用
HRID 424914作成日：2026年10月26日
Methyl 3,3,3-trifluoro-2-oxopropanoate → 1-(4-chlorophenyl)-2,5-dihydro-alpha-hydroxy-3-methyl-5-oxo-alpha-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester
https://huagongshe.com/reaction/424914
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl 3,3,3-trifluoro-2-oxopropanoate | HCID 2734931 | — |
| 反応物 | 2-(4-Chlorophenyl)-5-methyl-1H-pyrazol-3(2H)-one | HCID 3442874 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 1-(4-chlorophenyl)-2,5-dihydro-alpha-hydroxy-3-methyl-5-oxo-alpha-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester | HCID 44139819 | — |
反応手順
To a chloroform solution (5 ml) of 1-(4-chlorophenyl)-3-methyl-5-pyrazolone (104 mg, 0.5 mmol), methyl trifluoropyruvate (78 mg, 0.5 mmol) was added at room temperature and the mixture was stirred at 80° C. for 2 hours. After removing the solvent under reduced pressure, the title compound was obtained as a colorless solid (182 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08106086B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
|---|
| ORD ID | ord-e79a7b146dc941908744a9ae7843889e |
|---|
| 出典メモ | uspto-grants-2012_01 |
|---|
