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Triethylamine → Methanesulfonic acid 2-(5-bromo-benzothiazol-2-yl)-ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | 5-Bromo-2-benzothiazoleethanol | HCID 21980060 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Methanesulfonic acid 2-(5-bromo-benzothiazol-2-yl)-ethyl ester | HCID 21041502 | — |
反応手順
To a mixture of 2-(5-bromo-benzothiazol-2-yl)-ethanol (0.94 g, 3.6 mmol) in 10 mL CH2Cl2, Et3N (0.99 g, 9.8 mmol), was added methanesulfonyl chloride (0.46 g, 4.0 mmol) dropwise at room temperature. The reaction was worked up by concentrating under vacuum and then used in the next step, Example 1C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08106088B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-e7dcb545557e41e8b09838c68bacf468 |
| 出典メモ | uspto-grants-2012_01 |