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L-Prolinamide → [(1R,2S)-1-Benzyl-3-([2S]-2-carbamoyl-pyrrolidin-1-yl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Prolinamide | HCID 111306 | — |
| 反応物 | erythro-N-Boc-D-phenylalanine epoxide | HCID 11357515 | — |
| 生成物 | [(1R,2S)-1-Benzyl-3-([2S]-2-carbamoyl-pyrrolidin-1-yl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester | HCID 66703646 | — |
反応手順
Using general procedure 1 and purification method D with [(1R)-1-{(2R)-oxiran-2-yl}-2-phenyl-ethyl]carbamic acid tert-butylester (0.10 g, 0.38 mmol) and (S)-proline amide (0.114 g, 0.57 mmol) gives the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08106090B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-c1aac20363f64239b064bf073c992b70 |
| 出典メモ | uspto-grants-2012_01 |