erythro-N-Boc-D-phenylalanine epoxide → [(1R,2S)-3-Benzotriazol-2-yl-1-benzyl-2-hydroxy-propyl]-carbamic acid tert-butyl ester

HRID 424989

反応式

HRID 424989 の反応式
[C:1]([O:5][C:6](=[O:19])[NH:7][C@@H:8]([C@@H:16]1[CH2:18][O:17]1)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[NH:20]1[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[N:22]=[N:21]1>>[C:1]([O:5][C:6](=[O:19])[NH:7][C@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C@@H:16]([OH:17])[CH2:18][N:21]1[N:22]=[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]2=[N:20]1)([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 11357515erythro-N-Boc-D-phenylalanine epoxideHCID 178418385HCID 178418385、化合物

生成物 1

HCID 66703744[(1R,2S)-3-Benzotriazol-2-yl-1-benzyl-2-hydroxy-propyl]-carbamic acid tert-butyl ester

実験手順

Using general procedure 4 and purification method E (elute with isocratic 20% ethyl acetate/hexanes in this case) with [(1R)-1-{(2R)-oxiran-2-yl}-2-phenyl-ethyl]carbamic acid tert-butylester (0.25 g, 0.95 mmol) and 1,2,3-benzotriazole (0.136 g, 1.14 mmol) gives the title compound.

後処理

  1. customgeneral procedure 4 and purification method E (

出典と根拠

ORDレコード
ord-23e1f0bcd1424293a0868236f64b31a0
出典データセット
uspto-grants-2012_01
特許番号
US08106090B2

関連ノート

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