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Dimethylformamide → N'-(2-bromophenyl)sulfonyl-N,N-dimethylmethanimidamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 反応物 | Sodium Bisulfate | HCID 516919 | — |
| 反応物 | 2-Bromobenzenesulfonamide | HCID 2801263 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N'-(2-bromophenyl)sulfonyl-N,N-dimethylmethanimidamide | HCID 11779014 | — |
反応手順
The starting material, 2-bromobenzene-1-sulfonamide, is commercially available. Reaction of 2-bromobenzene-1-sulfonamide in a solvent such as DMF, with 1,1-dimethoxy-N,N-dimethylmethanamine, followed by the addition of sodium hydrogen sulfate in water, yields 2-bromo-N-[1-dimethylaminometh-(E)-ylidene]benzene-sulfonamide. This compound is reacted with 4-methylphenylboronic acid to yield 4′-methylbiphenyl-2-sulfonic acid 1-dimethylaminometh-(E)-ylideneamide, then the —(CH2)r-L moiety is added, for example, by a halogenation reaction, to form compound (1c).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08106082B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-0e40447194914754a69e1071fc4b0167 |
| 出典メモ | uspto-grants-2012_01 |