Methanol → Methyl 4-bromo-3-fluorobenzeneacetate

HRID 425329ノート

反応式

HRID 425329 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#N)=[CH:4][C:3]=1[F:11].S(=O)(=O)(O)O.[OH2:17].[CH3:18][OH:19]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:19][CH3:18])=[O:17])=[CH:4][C:3]=1[F:11]

参加物

5

反応物 4

HCID 887MethanolHCID 962WaterHCID 1118Sulfuric AcidHCID 116009532-(4-Bromo-3-fluorophenyl)acetonitrile

生成物 1

HCID 71265948Methyl 4-bromo-3-fluorobenzeneacetate

実験手順

(4-bromo-3-fluorophenyl)acetonitrile (40 g, 0.18 mol) was dissolved in 120 mL methanol, and 65 mL concentrated sulfuric acid were added. After heating at reflux overnight, the reaction mixture was cooled, and poured into 600 mL water, and the product was extracted with CH2Cl2. The combined extracts were washed with 10% sodium carbonate solution, dried, and concentrated to afford methyl (4-bromo-3-fluorophenyl)acetate.

後処理

  1. temperatureAfter heating
  2. temperatureat reflux overnight
  3. temperaturethe reaction mixture was cooled
  4. extractionthe product was extracted with CH2Cl2
  5. washThe combined extracts were washed with 10% sodium carbonate solution
  6. customdried
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-c486df2e7ae841448520cfd8662d0b6a
出典データセット
uspto-grants-2012_01
特許番号
US08106070B2

反応ノート

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