関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisobutylaluminum hydride | HCID 14487 | — |
| 反応物 | Methyl 4-chloroquinazoline-6-carboxylate | HCID 18925080 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (4-Chloroquinazolin-6-yl)methanol | HCID 57469640 | 68.5% |
反応手順
To a solution of methyl-4-chloroquinazoline-6-carboxylate (3.5 g, 0.015 mol) in dry THF (35 mL) at −25° C. was added DIBAL-H (4.4 g, 0.031 mol) and stirred at −25° C. to RT for 2 h. The reaction mixture was cooled to −10° C. and quenched with 10% aqueous NaHCO3 (9 mL). The reaction mixture was extracted with ethylacetate (100 mL), washed with water, brine and dried. The solvent was removed under vacuum to give 4-chloroquinazoline-6-yl methanol (2 g, 66%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08106214B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
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| ORD ID | ord-ebf3c2ba782f47bf838d1fa2bf29ff02 |
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| 出典メモ | uspto-grants-2012_01 |
|---|
