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Triacetoxyperiodinane → 4-Chloroquinazoline-6-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triacetoxyperiodinane | HCID 159087 | — |
| 反応物 | (4-Chloroquinazolin-6-yl)methanol | HCID 57469640 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Chloroquinazoline-6-carbaldehyde | HCID 57469639 | 88% |
反応手順
To a solution of 4-chloroquinazoline-6yl methanol (3.5 g, 0.018 mol) in dry CH2Cl2 (100 mL) was added Dess-Martin periodinane (8.4 g, 0.019 mol) and stirred at RT for 30 min. The reaction mixture was washed with 10% aqueous NaHCO3 (75 mL), water, brine and dried. The solvent was removed under vacuum to give 4-chloroquinazoline-6-carboxaldehyde (3 g, 88%) as pale yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08106214B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-9184dab4e007418a8605ef25bf6bb5d8 |
| 出典メモ | uspto-grants-2012_01 |