2-Amino-5-m-tolyl-thiazole-4-carboxylic acid → 6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-(1S,2S,5R)-{3-[2-amino-5-(3-methyl-phenyl)-thiazole-4-carbonyl]-3-aza-bicyclo[3.3.0]oct-2-ylmethyl}-amide

HRID 425873ノート

反応式

HRID 425873 の反応式
[C@H:1]12[CH2:8][CH2:7][CH2:6][C@H:5]1[CH2:4][NH:3][C@@H:2]2[CH2:9][NH:10][C:11]([C:13]1[N:20]2[C:16]([S:17][CH:18]=[CH:19]2)=[N:15][C:14]=1[CH3:21])=[O:12].[NH2:22][C:23]1[S:24][C:25]([C:31]2[CH:36]=[CH:35][CH:34]=[C:33]([CH3:37])[CH:32]=2)=[C:26]([C:28](O)=[O:29])[N:27]=1>>[NH2:22][C:23]1[S:24][C:25]([C:31]2[CH:36]=[CH:35][CH:34]=[C:33]([CH3:37])[CH:32]=2)=[C:26]([C:28]([N:3]2[CH2:4][C@H:5]3[C@H:1]([CH2:8][CH2:7][CH2:6]3)[C@H:2]2[CH2:9][NH:10][C:11]([C:13]2[N:20]3[C:16]([S:17][CH:18]=[CH:19]3)=[N:15][C:14]=2[CH3:21])=[O:12])=[O:29])[N:27]=1

参加物

3

反応物 2

HCID 532717422-Amino-5-m-tolyl-thiazole-4-carboxylic acidHCID 594116126-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-[(1S,2S,5R)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

生成物 1

HCID 251547036-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-(1S,2S,5R)-{3-[2-amino-5-(3-methyl-phenyl)-thiazole-4-carbonyl]-3-aza-bicyclo[3.3.0]oct-2-ylmethyl}-amide

実験手順

prepared by reaction of 6-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-[(1S,2S,5R)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide with 2-amino-5-(3-methyl-phenyl)-thiazole-4-carboxylic acid.

出典と根拠

ORDレコード
ord-34a717847f574252b0d26cdefbb5de42
出典データセット
uspto-grants-2012_01
特許番号
US08106215B2

反応ノート

読み込み中…