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HRID 425879作成日：2026年10月25日

2,3-Dihydro-1-benzofuran-4-carboxylic acid → 2,3-Dihydro-benzofuran-4-carboxylic acid-(1S,2S,5R)-[7,7-difluoro-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

https://huagongshe.com/reaction/425879

反応式

関与物質

役割名称HCID仕込み量
反応物2,3-Dihydro-1-benzofuran-4-carboxylic acidHCID 18787444—
反応物(1S,2S,5R)-(2-aminomethyl-7,7-difluoro-3-aza-bicyclo[3.3.0]-oct-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanoneHCID 59411607—
生成物2,3-Dihydro-benzofuran-4-carboxylic acid-(1S,2S,5R)-[7,7-difluoro-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amideHCID 25154154—

反応手順

prepared by reaction of (1S,2S,5R)-(2-aminomethyl-7,7-difluoro-3-aza-bicyclo[3.3.0]-oct-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 2,3-dihydro-benzofuran-4-carboxylic acid.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08106215B2
出典データセットuspto-grants-2012_01
ORD IDord-added624010c47919da8acc8059c4459
出典メモuspto-grants-2012_01