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4-(2-Morpholin-4-ylethoxy)benzeneboronic acid, pinacol ester → 3-(2,6-Dichloro-benzyloxy)-5-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-pyridin-2-ylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(2-Morpholin-4-ylethoxy)benzeneboronic acid, pinacol ester | HCID 4625910 | — |
| 反応物 | 3-(2,6-Dichlorobenzyloxy)-5-bromopyridin-2-amine | HCID 21111487 | — |
| 生成物 | 3-(2,6-Dichloro-benzyloxy)-5-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-pyridin-2-ylamine | HCID 10254297 | — |
反応手順
3-(2,6-Dichloro-benzyloxy)-5-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-pyridin-2-ylamine was prepared from 5-bromo-3-(2,6-dichloro-benzyloxy)-pyridin-2-ylamine (example I(a)) and 4-{2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-ethyl}-morpholine (prepared in part 1) following procedure 3 as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08106197B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-f3fd9ab8870d4a6aa11bd87ef76578f7 |
| 出典メモ | uspto-grants-2012_01 |