1,1-Dichloroethane → 2-(cyclohexylamino)-6-fluoro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide

HRID 425988ノート

反応式

HRID 425988 の反応式
CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.ClC(Cl)C.[CH:29]1([NH:35][C:36]2[N:44]=[C:43]([F:45])[CH:42]=[CH:41][C:37]=2[C:38]([OH:40])=O)[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1.[NH2:46][C:47]1[CH:56]=[C:55]2[C:50]([CH2:51][CH2:52][C:53](=[O:58])[N:54]2[CH3:57])=[CH:49][CH:48]=1>C(N(CC)CC)C>[CH:29]1([NH:35][C:36]2[N:44]=[C:43]([F:45])[CH:42]=[CH:41][C:37]=2[C:38]([NH:46][C:47]2[CH:56]=[C:55]3[C:50]([CH2:51][CH2:52][C:53](=[O:58])[N:54]3[CH3:57])=[CH:49][CH:48]=2)=[O:40])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]1

参加物

6

反応物 4

HCID 63651,1-DichloroethaneHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 336993947-amino-1-methyl-3,4-dihydroquinolin-2(1H)-oneHCID 667038262-(Cyclohexylamino)-6-fluoronicotinic acid

生成物 1

HCID 667038732-(cyclohexylamino)-6-fluoro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

HATU was added to a dichloroethane solution of 2-(cyclohexylamino)-6-fluoronicotinic acid and triethylamine. After 30 minutes of stirring at room temperature, 7-amino-1-methyl-3,4-dihydroquinolin-2(1H)-one was added thereto. The reaction liquid was stirred overnight at room temperature and then hearted under reflux for 3 hours. By post-treating the reaction liquid, 2-(cyclohexylamino)-6-fluoro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide was obtained.

後処理

  1. customThe reaction liquid
  2. stirringwas stirred overnight at room temperature
  3. temperatureunder reflux for 3 hours
  4. additionBy post-treating
  5. customthe reaction liquid

出典と根拠

ORDレコード
ord-77eb0c87536246de8af8a5379615cd1e
出典データセット
uspto-grants-2012_01
特許番号
US08106190B2

反応ノート

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