Nicotinic Acid → 3-Pyridinecarbonyl chloride, hydrochloride (1:1)

HRID 42620

反応式

HRID 42620 の反応式
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.O=P(Cl)(Cl)[Cl:12]>>[ClH:12].[C:1]([Cl:12])(=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1

参加物

3

反応物 2

HCID 938Nicotinic AcidHCID 24813Phosphorus oxychloride

生成物 1

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)

実験手順

A solution of nicotinic acid (0.50 g, 4.0 mmol) and POCl3 (5 mL) was heated at reflux for 1.5 h and concentrated. The product obtained was directly used in the next reaction.

後処理

  1. temperatureat reflux for 1.5 h
  2. concentrationconcentrated
  3. customThe product obtained
  4. customwas directly used in the next reaction

出典と根拠

ORDレコード
ord-d0bbcd6f753245b1a3784a550e794017
出典データセット
uspto-grants-2013_09
特許番号
US08536194B2

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