Nicotinic Acid → 3-Pyridinecarbonyl chloride, hydrochloride (1:1)
反応式
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.O=P(Cl)(Cl)[Cl:12]>>[ClH:12].[C:1]([Cl:12])(=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1参加物
3
実験手順
A solution of nicotinic acid (0.50 g, 4.0 mmol) and POCl3 (5 mL) was heated at reflux for 1.5 h and concentrated. The product obtained was directly used in the next reaction.
後処理
- temperatureat reflux for 1.5 h
- concentrationconcentrated
- customThe product obtained
- customwas directly used in the next reaction
出典と根拠
- ORDレコード
- ord-d0bbcd6f753245b1a3784a550e794017
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536194B2
反応ノート
読み込み中…