Ammonium Hydroxide → N-(4-(hydroxymethyl)pyridin-2-yl)acetamide
反応式
[C:1]([NH:4][C:5]1[CH:10]=[C:9]([CH2:11][O:12]C(=O)C)[CH:8]=[CH:7][N:6]=1)(=[O:3])[CH3:2].[OH-].[NH4+]>CO>[OH:12][CH2:11][C:9]1[CH:8]=[CH:7][N:6]=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[CH:10]=1参加物
4
実験手順
Acetic acid 2-acetylamino-pyridin-4-ylmethyl ester (4.2 g, 20 mmol) was stirred with ammonium hydroxide (10 ml) in methanol (50 ml) at room temperature. After 24 hr., the mixture was evaporated in vacuo and the residue was purified by silica gel column chromatography (eluent, EA) to afford 3.36 g (quantitative) of N-(4-hydroxymethyl-pyridin-2-yl)-acetamide as a pale yellow solid. m.p. 145° C.; 1H NMR (200 MHz, CDCl3/CD3OD) δ 2.19 (3H, s), 4.67 (2H, s), 7.08 (1H, d, J=5.0 Hz), 8.10 (1H, s), 8.17 (1H, d, J=5.0 Hz).
後処理
- custom, the mixture was evaporated in vacuo
- customthe residue was purified by silica gel column chromatography (eluent, EA)
出典と根拠
- ORDレコード
- ord-74b0f4f33b4f4d9f8eaad8c8ea8668fd
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08106064B2
反応ノート
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