Cyclohexylamine → N-Cyclohexylacetoacetamide

HRID 426542

反応式

HRID 426542 の反応式
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:8]=[C:9]1[O:13][C:11](=[O:12])[CH2:10]1>C1C=CC=CC=1>[CH:1]1([NH:7][C:11](=[O:12])[CH2:10][C:9](=[O:13])[CH3:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 7965CyclohexylamineHCID 12661Diketene

生成物 1

HCID 70805N-Cyclohexylacetoacetamide

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

反応条件

温度
20 °C

実験手順

A mixture of 500 ml of benzene and 99 g of cyclohexyl amine were introduced over 30 minutes to 84 g of diketene and after stirring for 4 hours at 20° C., the mixture was evaporated to dryness by distillation under reduced pressure. The residue was taken up in isopropyl ether and the solution was cooled and vacuum filtered. The recovered precipitate was dried and crystallized from isopropyl ether to obtain 137 g of N-cyclohexyl-acetylacetamide melting at 74° C.

後処理

  1. customthe mixture was evaporated to dryness by distillation under reduced pressure
  2. temperaturethe solution was cooled
  3. filtrationvacuum filtered
  4. customThe recovered precipitate was dried
  5. customcrystallized from isopropyl ether

出典と根拠

ORDレコード
ord-1badeddcfd504b04a8ef06cf61e0a4a7
出典データセット
uspto-grants-1979_10
特許番号
US04170465

関連ノート

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