Cyanamide → Metiamide

HRID 426676ノート

反応式

HRID 426676 の反応式
[S].[CH3:2][NH:3][C:4]([NH:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[N:12]=[CH:13][NH:14][C:15]=1[CH3:16])=[S:5].[N:17]#[C:18][NH2:19]>[Hg].N#CN.[Cd]>[C:18]([NH:19][C:4]([NH:3][CH3:2])=[N:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[N:12]=[CH:13][NH:14][C:15]=1[CH3:16])#[N:17].[CH3:2][NH:3][C:4]([NH:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[N:12]=[CH:13][NH:14][C:15]=1[CH3:16])=[S:5]

参加物

7

反応物 3

HCID 9864CyanamideHCID 1548992MetiamideHCID 5362487Sulfur

生成物 2

HCID 1548992MetiamideHCID 178484998HCID 178484998、化合物

試薬・触媒・溶媒 2

HCID 23931Mercury触媒HCID 86734572Cadmium;cyanamide触媒

実験手順

The compounds of Formula I wherein E is sulphur are also useful as intermediates for the procution of compounds of Formula I wherein E is NCN, for example, N-methyl-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiourea may be reacted with a heavy metal salt of cyanamide such as lead, mercury or cadmium cyanamide to yield N-cyano-N'-methyl-N"- [2-((5-methyl-4-imidazolyl)methylthio)ethyl]guanidine or N-methyl-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]-thiourea may be alkylated and the product reacted with cyanamide and a suitable strong base such as potassium t-butoxide to yield N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]guanidine.

出典と根拠

ORDレコード
ord-29e6ee77ebfc42a1b80c095b9700b82b
出典データセット
uspto-grants-1979_10
特許番号
US04171325

反応ノート

読み込み中…