Diazomethane → HCID 85913004、化合物

HRID 426780ノート

反応式

HRID 426780 の反応式
[C:1]([O:4][CH:5]1[C:9](=[O:10])[C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:7][CH2:6]1)(=[O:3])[CH3:2].[N+](=[CH2:22])=[N-]>C(OCC)C>[C:1]([O:4][CH:5]1[C:9](=[O:10])[C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19][CH3:22])=[O:18])=[CH:7][CH2:6]1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 9550DiazomethaneHCID 203899457-[4-(Acetyloxy)-5-oxocyclopent-1-en-1-yl]heptanoic acid

生成物 1

HCID 85913004HCID 85913004、化合物収率 100.7%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A solution of (±)-7-[4-acetoxy-5-oxo-cyclopent-1-enyl]heptanoic acid (1.0 g; prepared as described in Example 1) in dry diethyl ether (10 ml) was treated with a solution of diazomethane (0.32 g) in dry diethyl ether (5 ml). The reaction mixture was allowed to stand at ambient temperature for 2.5 hours. The diethyl ether and excess diazomethane were removed in vacuo to yield methyl (±)-7-[4-acetoxy-5-oxocyclopent-1-enyl]heptanoate (1.06 g). [νmax 1740 cm-1, 1720 cm-1, 1625 cm-1, 1380 cm-1, 1240 cm-1 ; λmax (ethanol) 232 mμ; N.M.R. (approximately 10% solution in deuterochloroform); multiplets at 7.28δ, 3.35-2.7δ, 2.7-2.2δ, 2.5-2.0δ, 2.0-1.05δ, doublet of doublets at 5.15δ (J=3 cycles/second and 7 cycles/second), singlets at 3.7δ and 2.1δ.] .

後処理

  1. customThe diethyl ether and excess diazomethane were removed in vacuo

出典と根拠

ORDレコード
ord-a0edea824111470d831650896b1d2c5d
出典データセット
uspto-grants-1979_10
特許番号
US04171375

反応ノート

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