Hydrochloric Acid → 1-[2-(2-Naphthyl)-2-(methoxy)ethyl]imidazole hydrochloride

HRID 426949ノート

反応式

HRID 426949 の反応式
[ClH:1].[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH:12]([O:19][CH3:20])[CH2:13][N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>>[ClH:1].[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH:12]([O:19][CH3:20])[CH2:13][N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 12698958HCID 12698958、化合物

生成物 1

HCID 126989591-[2-(2-Naphthyl)-2-(methoxy)ethyl]imidazole hydrochloride

実験手順

Ethereal hydrogen chloride is added dropwise to a stirred solution of 1.0 g. of 1-[2-(2-naphthyl)-2-(methoxy)ethyl]imidazole in 100 ml. of anhydrous ether until precipitation is complete. The product is filtered off, washed with ether, air dried and recrystallized from ethyl acetate/methanol to yield 1-[2-(2-naphthyl)-2-(methoxy)ethyl]imidazole hydrochloride, m.p. 171.5°-172.5° C.

後処理

  1. customof anhydrous ether until precipitation
  2. filtrationThe product is filtered off
  3. washwashed with ether, air
  4. customdried
  5. customrecrystallized from ethyl acetate/methanol

出典と根拠

ORDレコード
ord-9a4574fbc46e4c97bb3842766b4d06b0
出典データセット
uspto-grants-1979_10
特許番号
US04172141

反応ノート

読み込み中…