Ammonia → HCID 20544454、化合物
反応式
O.[O:2]=[C:3]1[CH:8]=[C:7]([CH2:9][OH:10])O[CH:5]=[C:4]1[O:11][CH2:12][C:13]([O:15]CC)=[O:14].[NH3:18]>>[O:2]=[C:3]1[CH:8]=[C:7]([CH2:9][OH:10])[NH:18][CH:5]=[C:4]1[O:11][CH2:12][C:13]([OH:15])=[O:14]参加物
3
反応条件
- 温度
- 120 °C
実験手順
A mixture of ethyl 2-(4-oxo-6-hydroxymethyl-4H-pyran-3-yloxy)acetate monohydrate (10 g) in conc. ammonia was heated at 120° C. for 10 hours in a sealed vessel and the reaction mixture was concentrated. To the residue was added water and the resultant solution was adjusted to pH 1 to 2 with 10% hydrochloric acid. The resultant precipitates were washed with water and dried to give crystals (6 g) of 2-(4-oxo-6-hydroxymethyl-1,4-dihydropyridin-3-yloxy)acetic acid.
後処理
- concentrationthe reaction mixture was concentrated
- additionTo the residue was added water
- customThe resultant precipitates
- washwere washed with water
- customdried
出典と根拠
- ORDレコード
- ord-df5eb099dd8f4019aae607684896a95f
- 出典データセット
- uspto-grants-1979_10
- 特許番号
- US04172198
反応ノート
読み込み中…