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Pyridine → 2-Acetamido-3-methylpyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | 2-Amino-3-methylpyridine | HCID 15347 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Acetamido-3-methylpyridine | HCID 268295 | — |
| 生成物 | 2-Methyl-7-azaindole | HCID 583066 | — |
反応手順
2-methyl-7-azaindole was prepared in two steps. First, 2-amino-3-picoline was reacted with acetyl chloride in toluene in the presence of pyridine to produce 2-acetamido-3-picoline in 65% yield. Second, pyrolysis of 2-acetamido-3-picoline in N-methylaniline in the presence of NaH at 280° C. was performed to produce 2-methyl-7-azaindole (FIG. 18) in 23% yield. This compound was characterized by NMR spectroscopy.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06312835B1 |
| 出典データセット | uspto-grants-2001_11 |
| ORD ID | ord-a4917c4c5f0c459ab8bd0167c09b9703 |
| 出典メモ | uspto-grants-2001_11 |