化工社化工社 化学情報印刷レポート · 研究参考用
Water → Ethyl 4-(piperidin-1-yl)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Ethyl 4-(piperidin-1-yl)benzoate | HCID 13813852 | — |
反応手順
Reaction of ethyl 4-fluorobenzoate with piperidine (3 equivalents) in acetonitrile was carried out at reflux for 4 days. Dilution of the cooled reaction mixture with several volumes of water provided a precipitate, which was filtered to provide ethyl 4-(piperidin-1-yl)benzoate. Reduction of the ester with lithium aluminum hydride (2 equivalents) in tetrahydrofuran gave the corresponding alcohol (Examples 71, 72).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06313100B1 |
| 出典データセット | uspto-grants-2001_11 |
| ORD ID | ord-c8b15264a4eb4c2e9a59dd9bdeae15d9 |
| 出典メモ | uspto-grants-2001_11 |