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Isobutylamine → Boc-Ile-NH-CH2-CH(CH3)2
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isobutylamine | HCID 6558 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | tert-Butoxycarbonyl-L-isoleucine | HCID 2724762 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Boc-Ile-NH-CH2-CH(CH3)2 | HCID 131722955 | — |
反応手順
In a DMF solution containing 2.0 g of Boc-Ile-OH, 0.82 ml of isobutylamine, 1.27 g of HOBt and 2.06 g of DCC were added under ice cooling and the resultant mixture was stirred for 14 hr. The reaction mixture, after filtration, was treated similarly to that in Example 50 (Process 2), except for the crystallization solvent (hexane) to give 1.44 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06313094B1 |
| 出典データセット | uspto-grants-2001_11 |
| ORD ID | ord-f043d0260b1949569a14578a54763201 |
| 出典メモ | uspto-grants-2001_11 |