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Benzaldehyde → 1-(4-Cinnamoylphenyl)-4-(4-pyridyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | 1-(4-Acetylphenyl)-4-(4-pyridyl)piperazine | HCID 18357135 | — |
| 触媒 | Sodium Hydroxide | HCID 14798 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-(4-Cinnamoylphenyl)-4-(4-pyridyl)piperazine | HCID 53679170 | 50.3% |
反応手順
A solution of 1-(4-acetylphenyl)-4-(4-pyridyl)piperazine (1.0 g), benzaldehyde (177 mg) and concentrated sodium hydroxide (3 drops) in ethanol (25 ml) was stirred at ambient temperature overnight to give a solid which was filtered, washed with ethanol and dried to give 1-(4-cinnamoylphenyl)-4-(4-pyridyl)piperazine (310 mg), m.p. 208-210° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06313127B1 |
| 出典データセット | uspto-grants-2001_11 |
| ORD ID | ord-0eaeb2ce37d845478c23552ddb4c4c49 |
| 出典メモ | uspto-grants-2001_11 |