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HRID 427494作成日：2026年10月27日
Dimethylformamide → 2,3-Dimethyl-8-(2-bromo-6-methylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxamide
https://huagongshe.com/reaction/427494
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1-Bromo-2-(chloromethyl)-3-methylbenzene | HCID 18357434 | — |
| 反応物 | 8-Amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide mesylate | HCID 18357435 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2,3-Dimethyl-8-(2-bromo-6-methylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxamide | HCID 9865017 | 9.3% |
反応手順
8-Amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide mesylate (1.0 g, 5.0 mmol), 2-bromo-6-methylbenzylchloride (45%)(3.0 g, 5.0 mmol) and diisopropylethylamin (2.2 g, 17 mmol) were added to dimethylformamide (50 ml) and stirred at 50° C. for 48 h. Methylene chloride and water were added to the reaction mixture, the organic layer was separated, washed with saturated sodium chloride, dried (Na2SO4) and evaporated under reduced pressure. Purification of the residue twice by column chromatography on silica gel using methylene chloride:methanol (10:1) and ethylacetate as eluent gave 0.18 g (1%) of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06313137B1 |
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| 出典データセット | uspto-grants-2001_11 |
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| ORD ID | ord-2e3679b0ebe64071937205063e296722 |
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| 出典メモ | uspto-grants-2001_11 |
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