Ethyl 2-chloroacetoacetate → Ethyl 8-amino-6-(aminocarbonyl)-2-methylimidazo[1,2-a]pyridine-3-carboxylate

HRID 427506ノート

反応式

HRID 427506 の反応式
[NH2:1][C:2]1[C:3]([NH2:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH2:9])=[O:8].[CH2:12]([O:14][C:15](=[O:21])[CH:16](Cl)[C:17]([CH3:19])=O)[CH3:13]>C(O)C>[NH2:1][C:2]1[C:3]2[N:4]([C:16]([C:15]([O:14][CH2:12][CH3:13])=[O:21])=[C:17]([CH3:19])[N:11]=2)[CH:5]=[C:6]([C:7]([NH2:9])=[O:8])[CH:10]=1

参加物

4

反応物 2

HCID 11858Ethyl 2-chloroacetoacetateHCID 99421905,6-Diaminonicotinamide

生成物 1

HCID 18357447Ethyl 8-amino-6-(aminocarbonyl)-2-methylimidazo[1,2-a]pyridine-3-carboxylate収率 12%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5,6-Diaminonicotinamide (2.0 g, 13.4 mmol), ethyl-2-chloroacetoacetate (2.38 g, 14.4 mmol) and ethanol (40 ml) were refluxed for 20 h. The precipitate was isolated by filtration and washed with ethanol and diethyl ether. The solids were suspended in water, basified with a sodium hydroxide solution and isolated by filtration. Washing the solids with water and diethyl ether gave 0.42 g (12%) of the desired product.

後処理

  1. customThe precipitate was isolated by filtration
  2. washwashed with ethanol and diethyl ether
  3. customisolated by filtration
  4. washWashing the solids with water and diethyl ether

出典と根拠

ORDレコード
ord-2b22776d263345f19074e980817f6d80
出典データセット
uspto-grants-2001_11
特許番号
US06313137B1

反応ノート

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