Water → 2-(2-Bromo-3-methylphenyl)acetic acid

反応式

[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][C:10]#N.S(=O)(=O)(O)[OH:13].[OH2:17]>>[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([OH:13])=[O:17]

参加物

反応物 3

HCID 962Water2 回

HCID 1118Sulfuric Acid

HCID 226726132-(2-Bromo-3-methylphenyl)acetonitrile

生成物 1

HCID 183574462-(2-Bromo-3-methylphenyl)acetic acid収率 90.8%

実験手順

2-(2-bromo-3-methylphenyl)acetonitril (8.0 g, 0.038 mol) was added to a mixture of water (60 ml) and sulfuric acid (50 ml) and the mixture was refluxed overnight. After cooling to room temperature water (200 ml) was added and the mixture was extracted twice with methylene chloride. The methylene chloride extracts were combined, washed twice with water, dried and evaporated under reduced pressure to give 7.9 g (90.8%) of the title compound.