Ethanol → Ethyl 2-(2-bromo-3-methylphenyl)acetate

HRID 427516ノート

反応式

HRID 427516 の反応式
[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=[O:11].S(=O)(=O)(O)O.[CH2:18](O)[CH3:19]>>[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([O:12][CH2:18][CH3:19])=[O:11]

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 183574462-(2-Bromo-3-methylphenyl)acetic acid

生成物 1

HCID 18357438Ethyl 2-(2-bromo-3-methylphenyl)acetate

実験手順

2-(2-bromo-3-methylphenyl)acetic acid (7.9 g, 0.034 mol) and sulfuric acid (0.1 ml) were added to ethanol (25 ml) and the mixture was refluxed overnight. The solvent was evaporated and to the residue was added saturated sodium carbonate. The aqueous solution was extracted twice with diethyl ether, the organic extracts were combiened, washed twice with water, dried and evaporated under reduced pressure to give the desired product as an oil. (8.5 g,97.7%).

後処理

  1. temperaturethe mixture was refluxed overnight
  2. customThe solvent was evaporated and to the residue
  3. additionwas added saturated sodium carbonate
  4. extractionThe aqueous solution was extracted twice with diethyl ether
  5. washwashed twice with water
  6. customdried
  7. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-45b7bd54eed74222a9c186bc1d203dcd
出典データセット
uspto-grants-2001_11
特許番号
US06313137B1

反応ノート

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