p-Tolylacetic acid → N-[(4-methylphenyl)acetyl]alanine iso-butyl ester

HRID 428109

反応式

HRID 428109 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH2:19])[CH:13]([CH3:15])[CH3:14]>>[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH:19][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=1)[CH:13]([CH3:15])[CH3:14]

参加物

3

反応物 2

HCID 248474p-Tolylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

生成物 1

HCID 53936136N-[(4-methylphenyl)acetyl]alanine iso-butyl ester

実験手順

Following General Procedure I above, and using 4-methylphenylacetic acid (Aldrich) and L-alanine iso-butyl ester (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

後処理

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

出典と根拠

ORDレコード
ord-05fa498c4cec4d1aa21a39e8a203c47a
出典データセット
uspto-grants-2001_11
特許番号
US06313152B1

関連ノート

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