methyl [3-[2-[(E)-3-(3-pyridyl)acryloylamino]ethyl]phenoxy]acetate → (E)-N-[3-[(methyl-carbamoyl) methoxy]phenethyl]-3-(3-pyridyl)-2-propenoic acid amide

HRID 428136ノート

反応式

HRID 428136 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](/[CH:7]=[CH:8]/[C:9]([NH:11][CH2:12][CH2:13][C:14]2[CH:15]=[C:16]([CH:23]=[CH:24][CH:25]=2)[O:17][CH2:18][C:19]([O:21]C)=O)=[O:10])[CH:2]=1.[CH3:26][NH2:27].CO>CO>[CH3:26][NH:27][C:19]([CH2:18][O:17][C:16]1[CH:15]=[C:14]([CH:25]=[CH:24][CH:23]=1)[CH2:13][CH2:12][NH:11][C:9](=[O:10])/[CH:8]=[CH:7]/[C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)=[O:21]

参加物

4

反応物 2

HCID 20701346methyl [3-[2-[(E)-3-(3-pyridyl)acryloylamino]ethyl]phenoxy]acetateHCID 57454252Monomethylamine methanol

生成物 1

HCID 20701410(E)-N-[3-[(methyl-carbamoyl) methoxy]phenethyl]-3-(3-pyridyl)-2-propenoic acid amide収率 88%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl [3-[2-[(E)-3-(3-pyridyl)acryloylamino]-ethyl]phenoxy]acetate (0.34 g, 1.0 mmol) obtained in Example 94 was dissolved in methanol (6 ml) and 40% methylamine-methanol solution (0.8 ml) was added and stirred at room temperature for 17 hours. After concentrating the reaction mixture under reduced pressure, the residue was recrystallized to yield the titled compound (0.30 g, 88%).

後処理

  1. concentrationAfter concentrating the reaction mixture under reduced pressure
  2. customthe residue was recrystallized

出典と根拠

ORDレコード
ord-79678c02d7cc454e9768d133289dce14
出典データセット
uspto-grants-2001_11
特許番号
US06313153B1

反応ノート

読み込み中…