Triethylamine → 2-(3-Hydroxyphenyl)-2-hydroxyethyl-3-(3-pyridyl)-2-propenoic acid amide

HRID 428141

反応式

HRID 428141 の反応式
C(Cl)(=[O:6])C(C)(C)C.[N:8]1[CH:13]=[CH:12][CH:11]=[C:10](/[CH:14]=[CH:15]/[C:16]([OH:18])=O)[CH:9]=1.C(N(CC)CC)C.Cl.[NH2:27][CH2:28][CH:29](O)[C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([OH:36])[CH:31]=1>ClCCl>[OH:36][C:32]1[CH:31]=[C:30]([C:29](=[C:14]([CH2:15][CH2:16][OH:18])[C:10]2[CH:9]=[N:8][CH:13]=[CH:12][CH:11]=2)[C:28]([NH2:27])=[O:6])[CH:35]=[CH:34][CH:33]=1

参加物

6

反応物 4

HCID 8471Triethylamine2 回HCID 62493Pivaloyl chlorideHCID 776396trans-3-(3-Pyridyl)acrylic acidHCID 3016408Benzenemethanol, alpha-(aminomethyl)-3-hydroxy-, hydrochloride (1:1)

生成物 1

HCID 867575682-(3-Hydroxyphenyl)-2-hydroxyethyl-3-(3-pyridyl)-2-propenoic acid amide収率 66%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

Pivaloyl chloride (5.17 ml, 1.05 eq.) was added to a solution of trans-3-(3-pyridyl)acrylic acid (5.96 g, 40 mmol) and triethylamine (5.6 ml, 40 mmol) in dichloromethane (80 ml) and stirred at room temperature for 10 minutes. A solution of dl-α-aminomethyl-3-hydroxybenzylalcohol hydrochloride (7.58 g, 40 mmol) and triethylamine (11.1 ml, 80 mmol) in dichloromethane (80 ml) was added and stirred at room temperature for 1 hour. The precipitated crystal was collected to yield the titled compound (7.51 g, 66%).

後処理

  1. stirringstirred at room temperature for 1 hour
  2. customThe precipitated crystal was collected

出典と根拠

ORDレコード
ord-d7a1659b8b374b5da9ebb7985f2d5f57
出典データセット
uspto-grants-2001_11
特許番号
US06313153B1

関連ノート

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