1,3-Dimethyl 2-(4-bromo-2-nitrophenyl)propanedioate → 4-Bromo-2-nitrophenylacetic Acid

HRID 428284

反応式

HRID 428284 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](C(OC)=O)[C:9]([O:11]C)=[O:10])=[C:4]([N+:17]([O-:19])=[O:18])[CH:3]=1>Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[C:4]([N+:17]([O-:19])=[O:18])[CH:3]=1

参加物

3

反応物 1

HCID 157405961,3-Dimethyl 2-(4-bromo-2-nitrophenyl)propanedioate

生成物 1

HCID 2715514-Bromo-2-nitrophenylacetic Acid収率 89%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

Crude dimethyl 4-bromo-2-nitrophenylmalonate was heated at 110° C. in 40 mL of 6N hydrochloric acid for 24 hours and then cooled. The precipitate was collected by filtration, washed with water and dried to give 5.3 g (89% yield) of 4-bromo-2-nitrophenylacetic acid as an off white solid.

後処理

  1. temperaturecooled
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-1264b065d0ab4799bc5d122b6f411ed5
出典データセット
uspto-grants-2001_11
特許番号
US06313158B1

関連ノート

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