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HRID 428361作成日：2026年10月26日

2-Chloro-6,7-dimethoxy-4-quinazolinamine → Terazosin Hydrochloride Anhydrous

https://huagongshe.com/reaction/428361

反応式

関与物質

役割名称HCID仕込み量
反応物2-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 90235—
反応物1-(Tetrahydro-2-furoyl)piperazineHCID 2734641—
生成物Terazosin Hydrochloride AnhydrousHCID 4438373.3%

反応手順

The procedures of Example 9 were followed except that Compound 3 from Example 1 (3.0 grams, 16.3 mmole) and 4-amino-2-chloro-6,7-bismethoxy quinazoline III (3.8 grams, 16.1 mmole) were reacted to obtain 5.0 grams of Terazosin hydrochloride (Yield: 73%). After alkalification, 4.7 grams of white Terazosin solid was obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06313293B1
出典データセットuspto-grants-2001_11
ORD IDord-d20a34aff01f44b8851f5a208e4967f6
出典メモuspto-grants-2001_11