Ethyl 4-(4-chloro-2-nitrobenzoyl)-3-benzoyl-1H-pyrazole-5-carboxylate → ethyl 4-(4-chloro-2-aminobenzoyl)-3-benzoyl-1H-pyrazole-5-carboxylate

HRID 428431ノート

反応式

HRID 428431 の反応式
[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([C:6]([C:8]2[C:9]([C:18](=[O:25])[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[N:10][NH:11][C:12]=2[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[O:7])=[C:4]([N+:28]([O-])=O)[CH:3]=1>B#[Ni]>[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([C:6]([C:8]2[C:9]([C:18](=[O:25])[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[N:10][NH:11][C:12]=2[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[O:7])=[C:4]([NH2:28])[CH:3]=1

参加物

3

反応物 1

HCID 18358884Ethyl 4-(4-chloro-2-nitrobenzoyl)-3-benzoyl-1H-pyrazole-5-carboxylate

生成物 1

HCID 18358872ethyl 4-(4-chloro-2-aminobenzoyl)-3-benzoyl-1H-pyrazole-5-carboxylate収率 56%

試薬・触媒・溶媒 1

HCID 82791nickel boride (NiB)触媒

実験手順

Following a procedure similar to that described in Example 23(d), ethyl 4-(4-chloro-2-nitrobenzoyl)-3-benzoyl-1H-pyrazole-5-carboxylate (1.2 g, 2.81 mmol) was treated with nickel boride to afford crude product. The crude product was purified by flash chromatography eluting with hexanes:ethyl acetate (75:25-50:50) to give the title compound as a solid (620 mg, 56%).

後処理

  1. customto afford crude product
  2. customThe crude product was purified by flash chromatography
  3. washeluting with hexanes:ethyl acetate (75:25-50:50)

出典と根拠

ORDレコード
ord-acd8336ef3464b86830d341a31fb2911
出典データセット
uspto-grants-2001_11
特許番号
US06313290B1

反応ノート

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