Benzaldehyde → O-benzylbenzaldoxime

HRID 428433

反応式

HRID 428433 の反応式
C(O)C.C(=O)([O-])[O-].[K+].[K+].Cl.[CH2:11]([O:18][NH2:19])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[CH:20](=O)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>O>[CH2:11]([O:18][N:19]=[CH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

6

反応物 4

HCID 240BenzaldehydeHCID 702EthanolHCID 11430Potassium CarbonateHCID 102312Benzyloxyamine hydrochloride

生成物 1

HCID 561973O-benzylbenzaldoxime収率 119%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a mixture of ethanol (100 mL), potassium carbonate (8.98 g, 65 mmol), and O-benzylhydroxylamine hydrochloride (10.0 g, 62.7 mmol) was added benzaldehyde (6.65 g, 62.7 mmol). The mixture was refluxed for 5 hours, allowed to cool to room temperature, and diluted with water (500 mL). The aqueous solution was extracted with ethyl acetate (500 mL). The organic layer was washed with water, dried over magnesium sulfate, filtered, and concentrated by rotary evaporation to give the title compound as a yellow oil (14.96 g, 119%).

後処理

  1. temperatureThe mixture was refluxed for 5 hours
  2. extractionThe aqueous solution was extracted with ethyl acetate (500 mL)
  3. washThe organic layer was washed with water
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated by rotary evaporation

出典と根拠

ORDレコード
ord-f8f702d18cf34264a338a750d8a58202
出典データセット
uspto-grants-2001_11
特許番号
US06313290B1

関連ノート

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