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4-(1H-Indol-3-YL)cyclohexanone → 3-(4-oxocyclohexyl)-1H-indole-5-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(1H-Indol-3-YL)cyclohexanone | HCID 10846264 | — |
| 反応物 | 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1H-indole | HCID 15521973 | — |
| 生成物 | 3-(4-oxocyclohexyl)-1H-indole-5-carbonitrile | HCID 11241886 | 81% |
反応手順
This compound was prepared in the manner described above for intermediate 3a by replacing 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-1H-indole with 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-5-cyano-1H-indole (6 g) to afford 4.03 g (81%) of the title compound as a white solid: mp 162.5-164° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06313126B1 |
| 出典データセット | uspto-grants-2001_11 |
| ORD ID | ord-363ced524074411ea8c2145efb9a10ce |
| 出典メモ | uspto-grants-2001_11 |