関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 5-Bromo-2-oxindole | HCID 611193 | — |
| 反応物 | 5-Methyl-1H-imidazole-4-carbaldehyde | HCID 2795887 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 溶媒 | Piperidine | HCID 8082 | — |
| 生成物 | HCID 178433222 | HCID 178433222 | — |
反応手順
A mixture of 5-bromo-1,3-dihydro-2H-indol-2-one (0.3 g, 1.41 mmol) (Starting Material 6), and excess 4-methyl-5-imidazolecarboxaldehyde (0.25 g, 2.27 mmol) (Aldrich) in 1% piperidine in 2-propanol (6 mL) was heated at 90° C. for 4 h. Hot water (6 mL) was added. On cooling, the crystallized product was filtered off, washed with aqueous 2-propanol and dried. (Yield 0.44 g, 100%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06313310B1 |
|---|
| 出典データセット | uspto-grants-2001_11 |
|---|
| ORD ID | ord-aaf9cbd07db3496c87e20762bddfd593 |
|---|
| 出典メモ | uspto-grants-2001_11 |
|---|
