Diethyl (ethoxymethylene)malonate → Diethyl {[(1-ethyl-1H-pyrazol-5-yl)amino]methylene}malonate

関与物質

反応手順

A neat solution of 5-amino-1-ethylpyrazole (20.0 g, 180 mmol) and diethyl ethoxymethylenemalonate (42.8 g, 198 mmol) was heated at 120° C. for 5 h. This material was used directly without further purification. If needed, the product can be distilled at 154-160° C. (0.1 mm Hg) to afford the title compound as a liquid which solidified to afford the title compound as a pale colored solid: mp 50-53° C.

情報源と証拠