Ammonia → 4-Methoxyphenylbenzo[d]oxazole-4-carboxamide

HRID 429164ノート

反応式

HRID 429164 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:12](=[C:14]([C:18]([O:20]C)=O)[CH:15]=[CH:16][CH:17]=3)[N:13]=2)=[CH:5][CH:4]=1.[NH3:22]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:12](=[C:14]([C:18]([NH2:22])=[O:20])[CH:15]=[CH:16][CH:17]=3)[N:13]=2)=[CH:5][CH:4]=1

参加物

3

反応物 2

HCID 222Ammonia2 回HCID 14616764Methyl 2-(4-methoxyphenyl)benzoxazole-4-carboxylate

生成物 1

HCID 183546064-Methoxyphenylbenzo[d]oxazole-4-carboxamide

実験手順

Methyl 2-(4-methoxyphenyl)benzoxazole-4-carboxylate was dissolved in liquid ammonia (30 ml) and sealed in an autoclave. The reaction mixture was left at 55° C., 20 bar for >20 hours. Once the reaction was complete the ammonia was removed and the resulting solid recrystallised from boiling ethyl acetate and petrol.

後処理

  1. customsealed in an autoclave
  2. waitThe reaction mixture was left at 55° C.
  3. wait20 bar for >20 hours
  4. customwas removed
  5. customthe resulting solid recrystallised

出典と根拠

ORDレコード
ord-c7d6a33dc7ff4b5889dd41a8a1ce92ed
出典データセット
uspto-grants-2001_11
特許番号
US06316455B1

反応ノート

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