Hydrochloric Acid → 4-[(Aminothioxomethyl)-hydrazono]-4-phenylbutanamide
反応式
[NH2:1][NH:2][C:3]([NH2:5])=[S:4].O=[C:7]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:8][CH2:9][C:10]([NH2:12])=[O:11].Cl.O>CO>[NH2:5][C:3]([NH:2][N:1]=[C:7]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:8][CH2:9][C:10]([NH2:12])=[O:11])=[S:4]参加物
6
実験手順
Thiosemicarbazide (1.38 g, 15.1 mmol) was added to a solution of 4-oxo-4-phenyl-butyramide (1.63 g, 9.22 mmol), prepared in the previous step, in 50 ml of methanol plus 2.5 ml of 1 N HCl plus 2.5 ml of water and the reaction stirred at room temperature for 28 hours. The solid formed was collected by filtration and dried to give 1.73 g of a purple solid. Recrystallization of the solid from methanol gave the title compound (1.34 g, 58%) as a purple solid, mp 186-188° C.
後処理
- customThe solid formed
- filtrationwas collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-30aeca9f6a5745588b90d299c38e546f
- 出典データセット
- uspto-grants-2001_11
- 特許番号
- US06316467B1
反応ノート
読み込み中…