関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Methylbenzyl alcohol | HCID 6994 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-Amino-3-chloropyrazine | HCID 276224 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Amino-3-(2-methylbenzyloxy)pyrazine | HCID 13825975 | 41.5% |
反応手順
To a solution of 2-methylbenzyl alcohol (0.985 g) in N,N-dimethylformamide (10 ml) was added 62.8% sodium hydride (0.308 g) under a nitrogen atmosphere and then stirred for 30 minutes. 2-Amino-3-chloropyrazine (0.87 g) was added to the solution and the mixture was heated at 65° C. for 2 hours and poured onto crushed ice. The resulting precipitates were collected by filtration, washed with n-hexane, and dried in a desiccator to give 2-amino-3-(2-methylbenzyloxy)pyrazine (0.6 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04725601 |
|---|
| 出典データセット | uspto-grants-1988_02 |
|---|
| ORD ID | ord-163ac3e349334314939c73ed51b57929 |
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| 出典メモ | uspto-grants-1988_02 |
|---|
