Methanimidamide, N,N-diphenyl- → 2-(3-Iodobenzoyl)-3-phenylaminoacrylonitrile

HRID 429379

反応式

HRID 429379 の反応式
[I:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([CH2:7][C:8]#[N:9])=[O:6].[C:13]1([N:19](C2C=CC=CC=2)[CH:20]=N)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1(C)C=CC=CC=1.CCOCC>[I:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([C:7](=[CH:20][NH:19][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:8]#[N:9])=[O:6]

参加物

5

反応物 2

HCID 78296Methanimidamide, N,N-diphenyl-HCID 116231793-Iodobenzoylacetonitrile

生成物 1

HCID 670242742-(3-Iodobenzoyl)-3-phenylaminoacrylonitrile収率 62.5%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 2-(3-iodobenzoyl)acetonitrile (36.2 g, 133.5 mmol) and N,N-diphenylformamidine (26.2 g, 133.5 mmol) in toluene (200 ml) was heated at reflux under a nitrogen atmosphere. After 8 h, the reaction mixture was cooled to room temperature and diluted with ether (200 ml) to give 2-(3-iodobenzoyl)-3-phenylaminoacrylonitrile (31.2 g) as a solid.

後処理

  1. temperaturewas heated
  2. temperatureat reflux under a nitrogen atmosphere

出典と根拠

ORDレコード
ord-011e87efc5f549d19e59f703074df519
出典データセット
uspto-grants-2001_11
特許番号
US06316466B1

関連ノート

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