Hydroquinone → 1-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one

HRID 429509

反応式

HRID 429509 の反応式
BrC1C=CC(Br)=CC=1.[C:9]1(C=CC(O)=C[CH:11]=1)[OH:10].[F:17][C:18]([F:34])([F:33])[CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH2:28][C:29]([F:32])([F:31])[F:30])=[CH:23][CH:22]=1>>[CH3:11][C:9]([C:23]1[CH:22]=[C:21]([O:20][CH2:19][C:18]([F:33])([F:34])[F:17])[CH:26]=[CH:25][C:24]=1[O:27][CH2:28][C:29]([F:32])([F:31])[F:30])=[O:10]

参加物

4

反応物 3

HCID 785HydroquinoneHCID 78041,4-DibromobenzeneHCID 7371561,4-Bis(2,2,2-trifluoroethoxy)benzene

生成物 1

HCID 27360731-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one

実験手順

Compound [III] is prepared by a multi-stage process, comprising the conversion of 1,4dibromobenzene or hydroquinone to 1,4-bis(2,2,2-trifluoroethoxy)benzene, which is acetylated to form 2,5-bis(2,2,2-trifluoroethoxy)acetophenone. The acetophenone is then oxidized to form the corresponding benzoic acid derivative, which is then converted to its acid chloride and reacted either with 2-(aminomethyl)piperidine to form the Flecainide product in one step or with 2-(aminomethyl)pyridine, followed by catalytic hydrogenation of the pyridine ring, to form Flecainide in two steps.

出典と根拠

ORDレコード
ord-2015b7c274634551875f9de46f28afd5
出典データセット
uspto-grants-2001_11
特許番号
US06316627B1

関連ノート

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