Piperidine → Imidazolyl indolinone

HRID 429542

反応式

HRID 429542 の反応式
C([C:3]1[NH:4][CH:5]=[C:6](C=O)[N:7]=1)C.C1C=CC(C(Cl)(C2C(Cl)=CC=CC=2)C2C=CC=CC=2)=CC=1.N1CCCCC1.[NH:37]1[C:45]2[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=2)[CH2:39][C:38]1=[O:46]>CN(C=O)C>[NH:4]1[CH:5]=[CH:6][N:7]=[C:3]1[N:37]1[C:45]2[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=2)[CH2:39][C:38]1=[O:46]

参加物

6

反応物 4

HCID 8082PiperidineHCID 945242-Chlorotrityl chlorideHCID 321710OxindoleHCID 178437699HCID 178437699、化合物

生成物 1

HCID 23177814Imidazolyl indolinone

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 2-ethyl-4-formylimidazole attached to 2-chlorotrityl resin (4, 78 mg, 0.052 mmol based on 0.67 mmol/g loading), DMF (0.9 ml) and piperidine (0.1 ml) was gently stirred for 45 min. at ambient temperature, afterwhich was added 2-indolinone (5, 70 mg, 0.523 mmol). The resultant mixture was gently stirred and heated at 80° C. for 20 h. The resin was filtered and washed with 30 ml each of acetone, water, dichloromethane, methanol, and another portion of acetone. Finally, the resin was air dried for 20 min.

後処理

  1. temperatureheated at 80° C. for 20 h
  2. filtrationThe resin was filtered
  3. washwashed with 30 ml each of acetone, water, dichloromethane, methanol
  4. customdried for 20 min.

出典と根拠

ORDレコード
ord-1b5b360463e841348e693cf383eee8f6
出典データセット
uspto-grants-2001_11
特許番号
US06316635B1

関連ノート

読み込み中…